Research by Network

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A5263

Current Study

A Randomized Comparison of Three Regimens of Chemotherapy with Compatible Antiretroviral Therapy for Treatment of Advanced AIDS-KS in Resource Limited Settings Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) The National Canc …

ACTG

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A5300B

Current Study

Protecting Households on Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Participants (PHOENIx). Protocol summary: This trial is of household contacts (HHC) at high risk for developing multidrug resistant tuberculosis (MDR-TB) which …

ACTG

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A5332 REPRIEVE Trial

Current Study

Protocol summary: In this study, people between the ages of 40 and 75 with HIV will be randomized (like flipping a coin) to take the pill pitavastatin OR a placebo (non-active pill) to see if pitavastatin can help prevent heart disease and death in peo …

ACTG

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A5354

Current Study

This study evaluates whether starting antiretroviral drugs very early in HIV infection will limit the virus from getting into hidden areas of the body (reservoirs) and change how the immune system helps to control the virus. The study includes people w …

ACTG

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A5372

Current Study

Drug-Drug Interactions Between Rifapentine and Dolutegravir In HIV/LTBI Co-Infected Individuals (RPT-DTG PK Study). Study summary The purpose of this research study is to see if taking medications to prevent tuberculosis (TB) affect the drug levels in …

ACTG

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A5379

Current Study

B-Enhancement of HBV Vaccination in Persons Living with HIV (BEe-HIVe): Evaluation Of HEPLISAV-B Study summary A5379 is a study looking at hepatitis B vaccination in adults living with HIV. Hepatitis B is a serious viral infection that affects the live …

ACTG

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A5381

Current Study

Observational Cohort to Assess Therapeutic Efficacy And Emergence Of HIV Drug Resistance Following Initiation Of Tenofovir-Lamivudine-Dolutegravir (TLD) For First- Or Second-Line ART Protocol summary This is a study for people who have HIV and qualify …

ACTG

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A5349

Current Study

Rifapentine-containing treatment shortening regimens for pulmonary tuberculosis: A randomized, open-label, controlled phase 3 clinical trial. Protocol summary: The purpose of this study is to determine whether one or two four-month regimens of tubercul …

ACTG

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A5175

Completed Study

A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily PI & Once-Daily Non-NRTI – Containing Therapy Combinations for Initial Treatment of HIV-1 Infected individuals from Resource – Limited Settings (PEARLS) Trial …

ACTG

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A5185s

Completed Study

A Substudy of A5175: Effect of Initial Antiretroviral Treatment on Genital Compartment Virus in Individuals from Diverse Areas of the World Sponsor: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5185s was a substud …

ACTG

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A5199

Completed Study

International Neuropsychological Assessment of Patients Initiating Antiretroviral Therapy in Resource-Limited Settings Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) US National Institute of Mental Health Summary: A5199 was …

ACTG

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A5264

Completed Study

A Randomized Evaluation of Antiretroviral Therapy Alone or with Delayed Chemotherapy Versus Antiretroviral Therapy with Immediate Adjunctive Chemotherapy for Treatment of Limited Stage AIDS-KS in Resource Limited Settings Sponsors: US National Institut …

ACTG

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A5190/P1054

Completed Study

Assessment of Safety and Toxicity among Infants Born To HIV-1-Infected Women Enrolled in Antiretroviral Treatment Protocols in Diverse Areas of the World Sponsor: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5190- …

ACTG

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A5199

Completed Study

International Neuropsychological Assessment of Patients Initiating Antiretroviral Therapy in Resource-Limited Settings Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) US National Institute of Mental Health Summary: A5199 was …

ACTG

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A5208

Completed Study

Optimal Combination Therapy After Nevirapine Exposure (OCTANE) Sponsor: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5208 was a phase III study that comprised of two randomized clinical trials that were conducted …

ACTG

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A5221

Completed Study

A Strategy Study of Immediate Versus Deferred initiation of Antiretroviral Therapy for AIDS Disease-Free Survival in HIV-Infected Persons Treated for Tuberculosis with CD4 Sponsor: US National Institute of Allergy and Infectious Diseases (NIAID) Protoc …

ACTG

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A5225

Completed Study

A Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis Sponsor: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5225 was a phase I/II dose escalation and validat …

ACTG

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A5234

Completed Study

International Trial of Modified Directly Observed Therapy versus Self-Administered Therapy for Participants with First Virologic Failure on a Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Regimen Sponsor: US National Institut …

ACTG

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A5265

Completed Study

A Phase III, Open-Label, Randomized, Assessment-Blinded Clinical Trial to Compare the Safety and Efficacy of Topical Gentian Violet to that of Nystatin Oral Suspension for the Treatment of OC in HIV-1 Infected Participants in Non-US Settings Sponsors: …

ACTG

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A5273

Completed Study

Mulitcenter Study of Options for SEcond-Line Effective Combination Therapy (SELECT) Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5273 is a phase III, dual-arm, open-label, randomized, non-inferiority stu …

ACTG

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A5274

Completed Study

Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment Regimens Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5274 is a randomized, open-label, phase IV strategy trial, where parti …

ACTG

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A5278

Completed Study

Pharmacology Substudies of A5263 and A5264 Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID) The National Cancer Institute (NCI) National Institute on Dental Craniofacial Research (NIDCR) Protocol Summary: A5278 is designed to …

ACTG

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A5282

Completed Study

A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-based Strategy for Prevention of CIN 2+ in HIV-infected Women Sponsor: US National institute of Allergy and Infectious Diseases (NIAID) Protocol Summary: A5282 is a ra …

ACTG

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