Diaphragm and Lubricant Gel for Prevention of HIV Acquisition in Southern African Women: A Randomized, Controlled Trial (MIRA)

Sponsor: The Bill and Melinda Gates Foundation

Protocol Summary: MIRA was a multi-site, randomized, controlled study that sought to measure the effectiveness of the diaphragm, Replens gel and condoms versus condoms alone in preventing heterosexual acquisition of HIV infection among women. The study enrolled over 5,000 sexually active, HIV-negative women in South Africa and Zimbabwe who were followed for 12-24 months.

Years: 2003-2007

Investigator: Tsungai Chipato, MBChB, FRCOG, MCE

Locations: Epworth and Markoni CRSs (Protocol-specific sites)


Completed Study


Padian NS, van der Straten A, Ramjee G, Chipato T, de Bruyn G, et al. (2007) Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomized controlled trial. Lancet; 370(9583): 251-61.

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