Diaphragm and Lubricant Gel for Prevention of HIV Acquisition in Southern African Women: A Randomized, Controlled Trial (MIRA)

Sponsor: The Bill and Melinda Gates Foundation

Protocol Summary: MIRA was a multi-site, randomized, controlled study that sought to measure the effectiveness of the diaphragm, Replens gel and condoms versus condoms alone in preventing heterosexual acquisition of HIV infection among women. The study enrolled over 5,000 sexually active, HIV-negative women in South Africa and Zimbabwe who were followed for 12-24 months.

Years: 2003-2007

Investigator: Tsungai Chipato, MBChB, FRCOG, MCE

Locations: Epworth and Markoni CRSs (Protocol-specific sites)

Non-Network

Completed Study

Publication:

Padian NS, van der Straten A, Ramjee G, Chipato T, de Bruyn G, et al. (2007) Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomized controlled trial. Lancet; 370(9583): 251-61.