Pharmacology Substudies of A5263 and A5264
US National Institute of Allergy and Infectious Diseases (NIAID)
The National Cancer Institute (NCI)
National Institute on Dental Craniofacial Research (NIDCR)
A5278 is designed to assess the direction and magnitude of pharmacokinetic (PK) interactions between the antiretroviral agents efavirenz/tenofovir/emtricitabine (EFV/TDF/FTC) and the Karbosi’s sarcoma (KS) chemotherapy agents etoposide (ET), vincristine (VCR), and paclitaxel (PTX).
Years: 2013 – 2014
Investigator: Margaret Borok-Williams, MD, CHB, MMED
Location: Parirenyatwa CRS