A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-based Strategy for Prevention of CIN 2+ in HIV-infected Women
Sponsor: US National institute of Allergy and Infectious Diseases (NIAID)
Protocol Summary: A5282 is a randomized clinical trial that will compare a human papillomavirus (HPV) test-and-treat-strategy with a cytology based strategy. All participants will be screened with the Abbott RealTime high-risk HPV test (aHPV) to detect high risk HPV (hr-HPV) infection. The primary objective is to evaluate the effectiveness of immediate cryotherapy in HIV-Infected women with hr-HPV compared to a cytology-based strategy by comparing cumulative CIN2+ rates.
Years: 2013 – 2017
Investigator: Tsitsi Magure, MMED, MBChB
Location: Parirenyatwa CRS