HVTN 140/HPTN 101

Study Title: A phase 1 dose-escalation clinical trial to evaluate the safety, tolerability, and pharmacokinetics of PGDM1400LS alone and in combination with VRC07-523LS and PGT121.414.LS in healthy, HIV-uninfected adult participants

Study summary:

The primary objectives of this study are:  To evaluate the safety and tolerability of PGDM1400LSwhen administered via intravenous (IV) or subcutaneous (SC) routes (Part A) and of PGDM1400LS+ VRC07-523LS + PGT121.414.LS when administered in sequence IV or SC (Part B). The second objective is to evaluate the serum concentrations and pharmacokinetics of PGDM1400LS after a single administration (Part A) and of PGDM1400LS + VRC07-523LS + PGT121.414.LS after each three-mAb administration (Part B)

Location: Seke South CRS, Spilhaus CRS, Milton Park CRS


Current Study

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