HVTN 405/HPTN 1901

Study Title: Characterizing SARS-CoV-2-specific immunity in convalescent individuals

Study summary:

The primary objectives of the study are: 1) To identify serologic reactivities that differentiate SARS-CoV-2 infection from vaccination; 2) To develop and formally qualify a suite of immunologic assays and reference reagents that permit detailed interrogations of the immune response to SARSCoV-2 infection in preparation for similar assessments of vaccine-elicited immune responses and immunotherapeutics;  3) To measure SARS-CoV-2-specific adaptive immune responses in order to identify immune markers of COVID-19 disease severity and duration in different demographic groups (eg, age, gender) and in people with different medical histories, including pre-existing conditions, new acute or chronic medical conditions, and concomitant medications; and 4) To characterize presentations of SARS-CoV-2 infection, including the clinical course of COVID-19, among convalescent individuals. This is an observational cohort study of approximately 675-800 volunteers aged 18 or older.

Location: Seke South CRS, St Mary’s CRS and Zengeza CRS


Current Study

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